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The belief is that it enhances the effectiveness of radiation therapy either by reducing the number of cancer cells that have to be killed by radiotherapy or by making the cancer cells more sensitive to radiation or both.
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When it reaches the testicles, it binds to specialized cells that secrete testosterone into the bloodstream.
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If at any time a patient has jaundice, or their ALT rises above two times the upper limit of normal, Bicalutamide should be immediately discontinued with close follow-up of liver function.
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Data from larger cohorts support these findings, and indicate that TMPRSS2 fusion with ETS members is the most frequent rearrangement in prostate cancer.
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Loss of ejaculation is also normal after brachytherapy because the radiation from the seeds dries up the prostate secretions.
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Casodex 150 mg daily is not approved for use as therapy for patients with localized prostate cancer who are candidates for watchful waiting.
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The pharmaceutical compositions of the present invention contain bicalutamide form II as either the only bicalutamide form or as one of two or more forms.
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The recommended dose for CASODEX therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening), with or without food.
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Currently, PC treatment includes androgen deprivation, surgery, radiation, endocrine therapy and radical prostatectomy.
The EPC programme is ongoing and continued follow-up will provide further valuable information on the role of bicalutamide in the management of prostate cancer.
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